2,524 research outputs found
Cooling a single atom in an optical tweezer to its quantum ground state
We report cooling of a single neutral atom to its three-dimensional
vibrational ground state in an optical tweezer. After employing Raman sideband
cooling for tens of milliseconds, we measure via sideband spectroscopy a
three-dimensional ground-state occupation of ~90%. We further observe coherent
control of the spin and motional state of the trapped atom. Our demonstration
shows that an optical tweezer, formed simply by a tightly focused beam of
light, creates sufficient confinement for efficient sideband cooling. This
source of ground-state neutral atoms will be instrumental in numerous quantum
simulation and logic applications that require a versatile platform for storing
and manipulating ultracold single neutral atoms. For example, these results
will improve current optical tweezer experiments studying atom-photon coupling
and Rydberg quantum logic gates, and could provide new opportunities such as
rapid production of single dipolar molecules or quantum simulation in tweezer
arrays.Comment: Updated intro, titl
Seconds-scale coherence in a tweezer-array optical clock
Optical clocks based on atoms and ions achieve exceptional precision and
accuracy, with applications to relativistic geodesy, tests of relativity, and
searches for dark matter. Achieving such performance requires balancing
competing desirable features, including a high particle number, isolation of
atoms from collisions, insensitivity to motional effects, and high duty-cycle
operation. Here we demonstrate a new platform based on arrays of ultracold
strontium atoms confined within optical tweezers that realizes a novel
combination of these features by providing a scalable platform for isolated
atoms that can be interrogated multiple times. With this tweezer-array clock,
we achieve greater than 3 second coherence times and record duty cycles up to
96%, as well as stability commensurate with leading platforms. By using optical
tweezer arrays --- a proven platform for the controlled creation of
entanglement through microscopic control --- this work further promises a new
path toward combining entanglement enhanced sensitivities with the most precise
optical clock transitions
Long-range-enhanced surface codes
The surface code is a quantum error-correcting code for one logical qubit,
protected by spatially localized parity checks in two dimensions. Due to
fundamental constraints from spatial locality, storing more logical qubits
requires either sacrificing the robustness of the surface code against errors
or increasing the number of physical qubits. We bound the minimal number of
spatially non-local parity checks necessary to add logical qubits to a surface
code while maintaining, or improving, robustness to errors. We asymptotically
saturate this bound using a family of hypergraph product codes, interpolating
between the surface code and constant-rate low-density parity-check codes.
Fault-tolerant protocols for logical operations generalize naturally to these
longer-range codes, based on those from ordinary surface codes. We provide
near-term practical implementations of this code for hardware based on trapped
ions or neutral atoms in mobile optical tweezers. Long-range-enhanced surface
codes outperform conventional surface codes using hundreds of physical qubits,
and represent a practical strategy to enhance the robustness of logical qubits
to errors in near-term devices.Comment: 16 pages, 12 figures; v2 changes: fixed typos and added citation
Racial disparities in treatment patterns and clinical outcomes in patients with HER2-positive metastatic breast cancer.
Data characterizing demographics, treatment patterns, and clinical outcomes in black patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) are limited. registHER is a large, observational cohort study of patients (n = 1,001) with HER2-positive MBC diagnosed ≤6 months of enrollment and followed until death, disenrollment, or June 2009 (median follow-up of 27 months). Demographics, treatment patterns, and clinical outcomes were described for black (n = 126) and white patients (n = 793). Progression-free survival (PFS) following first-line therapy and overall survival (OS) were examined. Multivariate analyses adjusted for baseline and treatment factors. Black patients were more likely than white patients to be obese (body mass index ≥30), to have diabetes, and to have a history of cardiovascular disease; they were also less likely to have estrogen receptor or progesterone receptor positive disease. In patients treated with trastuzumab, the incidence of cardiac safety events (grade ≥3) was higher in black patients (10.9 %) than in white patients (7.9 %). Unadjusted median OS and PFS (months) were significantly lower in black patients than in white patients (OS: black: 27.1, 95 % confidence interval [CI] 21.3-32.1; white: 37.3, 95 % CI 34.6-41.1; PFS: black: 7.0, 95 % CI 5.7-8.2; white: 10.2, 95 % CI 9.3-11.2). The adjusted OS hazard ratio (HR) for black patients compared with white patients was 1.29 (95 % CI 1.00-1.65); adjusted PFS HR was 1.29 (95 % CI 1.05-1.59). This real-world evaluation of a large cohort of patients with HER2-positive MBC shows poorer prognostic factors and independently worse clinical outcomes in black versus white patients. Further research is needed to identify potential biologic differences that could have predictive impact for black patients or that could explain these differences
Ytterbium nuclear-spin qubits in an optical tweezer array
We report on the realization of a fast, scalable, and high-fidelity qubit
architecture, based on Yb atoms in an optical tweezer array. We
demonstrate several attractive properties of this atom for its use as a
building block of a quantum information processing platform. Its nuclear spin
of 1/2 serves as a long-lived and coherent two-level system, while its rich,
alkaline-earth-like electronic structure allows for low-entropy preparation,
fast qubit control, and high-fidelity readout. We present a near-deterministic
loading protocol, which allows us to fill a 1010 tweezer array with
92.73(8)% efficiency and a single tweezer with 96.0(1.4)% efficiency. In the
future, this loading protocol will enable efficient and uniform loading of
target arrays with high probability, an essential step in quantum simulation
and information applications. Employing a robust optical approach, we perform
submicrosecond qubit rotations and characterize their fidelity through
randomized benchmarking, yielding 5.2(5) error per Clifford
gate. For quantum memory applications, we measure the coherence of our qubits
with =3.7(4) s and =7.9(4) s, many orders of magnitude longer than
our qubit rotation pulses. We measure spin depolarization times on the order of
tens of seconds and find that this can be increased to the 100 s scale through
the application of a several-gauss magnetic field. Finally, we use 3D
Raman-sideband cooling to bring the atoms near their motional ground state,
which will be central to future implementations of two-qubit gates that benefit
from low motional entropy.Comment: Fixed typos, refined scattering model, adds T1 dat
Treatment patterns and clinical outcomes in elderly patients with HER2-positive metastatic breast cancer from the registHER observational study.
Limited data exist regarding treatment patterns and outcomes in elderly patients with HER2-positive metastatic breast cancer (MBC). registHER is an observational study of patients (N = 1,001) with HER2-positive MBC diagnosed within 6 months of enrollment and followed until death, disenrollment, or June 2009 (median follow-up 27 months). Outcomes were analyzed by age at MBC diagnosis: younger (<65 years), older (65-74 years), elderly (≥75 years). For progression-free survival (PFS) and overall survival (OS) analyses of first-line trastuzumab versus nontrastuzumab, older and elderly patients were combined. Cox regression analyses were adjusted for baseline characteristics and treatments. Estrogen receptor/progesterone receptor status was similar across age groups. Underlying cardiovascular disease was most common in elderly patients. In patients receiving trastuzumab-based first-line treatment, elderly patients were less likely to receive chemotherapy. In trastuzumab-treated patients, incidence of left ventricular dysfunction (LVD) and congestive heart failure (CHF) (grades ≥ 3) were highest in elderly patients (LVD: elderly 4.8 %, younger 2.8 %, older 1.5 %; CHF: elderly 3.2 %, younger 1.9 %, older 1.5 %). Unadjusted median PFS (months) was significantly higher in patients treated with first-line trastuzumab than those who were not (<65 years: 11.0 vs. 3.4, respectively; ≥65 years: 11.7 vs. 4.8, respectively). In patients <65 years, unadjusted median OS (months) was significantly higher in trastuzumab-treated patients; in patients ≥65 years, median OS was similar (<65 years: 40.4 vs. 25.9; ≥65 years: 31.2 vs. 28.5). In multivariate analyses, first-line trastuzumab use was associated with significant improvement in PFS across age. For OS, significant improvement was observed for patients <65 years and nonsignificant improvement for patients ≥65 years. Elderly patients with HER2-positive MBC had higher rates of underlying cardiovascular disease than their younger counterparts and received less aggressive treatment, including less first-line trastuzumab. These real-world data suggest improved PFS across all age groups and similar trends for OS
Enhancing spin squeezing using soft-core interactions
We propose a new protocol for preparing spin squeezed states in controllable
atomic, molecular, and optical systems, with particular relevance to emerging
optical clock platforms compatible with Rydberg interactions. By combining a
short-ranged, soft-core potential with an external drive, we can transform
naturally emerging Ising interactions into an XX spin model while opening a
many-body gap. The gap helps maintain the system within a collective manifold
of states where metrologically useful spin squeezing can be generated at a
level comparable to the spin squeezing generated in systems with genuine
all-to-all interactions. We examine the robustness of our protocol to
experimentally-relevant decoherence and show favorable performance over typical
protocols lacking gap protection.Comment: 5+4 pages, 3+3 figure
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